Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Mar 5:4:29.
doi: 10.3389/fcimb.2014.00029. eCollection 2014.

Shifting the paradigm from pathogens to pathobiome: new concepts in the light of meta-omics

Muriel Vayssier-Taussat  1 , Emmanuel Albina  2 , Christine Citti  3 , Jean-Franҫois Cosson  4 , Marie-Agnès Jacques  5 , Marc-Henri Lebrun  6 , Yves Le Loir  7 , Mylène Ogliastro  8 , Marie-Agnès Petit  9 , Philippe Roumagnac  10 , Thierry Candresse  11
Affiliations
Review

Shifting the paradigm from pathogens to pathobiome: new concepts in the light of meta-omics

Muriel Vayssier-Taussat et al. Front Cell Infect Microbiol. .

Abstract

The concept of pathogenesis has evolved considerably over recent years, and the scenario "a microbe + virulence factors = disease" is probably far from reality in a number of cases. Actual pathogens have extremely broad biological diversity and are found in all major groups of microorganisms (viruses, bacteria, fungi, protozoa…). Their pathogenicity results from strong and often highly specific interactions they have with either their microbial environment, hosts and/or arthropod vectors. In this review, we explore the contribution of metagenomic approaches toward understanding pathogens within the context of microbial communities. With this broader view, we discussed the concept of "pathobiome" and the research questions that this raises.

Keywords: interactions; microbial ecosystem; next generation sequencing.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overview of the pathobiome concept and scientific challenges for the coming years.
See this image and copyright information in PMC

References

    1. Akira S., Uematsu S., Takeuchi O. (2006). Pathogen recognition and innate immunity. Cell 124, 783–801 10.1016/j.cell.2006.02.015 - DOI - PubMed
    1. Anderson P. K., Cunningham A. A., Patel N. G., Morales F. J., Epstein P. R., Daszak P. (2004). Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology drivers. Trends Ecol. Evol. 19, 535–544 10.1016/j.tree.2004.07.021 - DOI - PubMed
    1. Barzon L., Lavezzo E., Militello V., Toppo S., Palu G. (2011). Applications of next-generation sequencing technologies to diagnostic virology. Int. J. Mol. Sci. 12, 7861–7884 10.3390/ijms12117861 - DOI - PMC - PubMed
    1. Beattie G. A., Lindow S. E. (1999). Bacterial colonization of leaves: a spectrum of strategies. Phytopathology 89, 353–359 10.1094/PHYTO.1999.89.5.353 - DOI - PubMed
    1. Beer M., Conraths F. J., van der Poel W. H. (2013). “Schmallenberg virus”–a novel orthobunyavirus emerging in Europe. Epidemiol. Infect. 141, 1–8 10.1017/S0950268812002245 - DOI - PMC - PubMed

Substances