Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Jean Bousquet¹, James E Gern², Fernando D Martinez³, Josep M Anto⁴, Christine C Johnson⁵, Patrick G Holt⁶, Robert F Lemanske Jr², Peter N Le Souëf⁷, Robert S Tepper⁸, Erika R M von Mutius⁹, S Hasan Arshad¹⁰, Leonard B Bacharier¹¹, Allan Becker¹², Kathleen Belanger¹³, Anna Bergström¹⁴, David I Bernstein¹⁵, Michael D Cabana¹⁶, Kecia N Carroll¹⁷, Mario Castro¹⁸, Philip J Cooper¹⁹, Matthew W Gillman²⁰, Diane R Gold²¹, John Henderson²², Joachim Heinrich²³, Soo-Jong Hong²⁴, Daniel J Jackson², Thomas Keil²⁵, Anita L Kozyrskyj²⁶, Karin C Lødrup Carlsen²⁷, Rachel L Miller²⁸, Isabelle Momas²⁹, Wayne J Morgan³⁰, Patricia Noel³¹, Dennis R Ownby³², Mariona Pinart³³, Patrick H Ryan³⁴, Julie M Schwaninger³⁵, Malcolm R Sears³⁶, Angela Simpson³⁷, Henriette A Smit³⁸, Debra A Stern³, Padmaja Subbarao³⁹, Rudolf Valenta⁴⁰, Xiaobin Wang⁴¹, Scott T Weiss⁴², Robert Wood⁴³, Anne L Wright⁴⁴, Rosalind J Wright⁴⁵, Alkis Togias³⁵, Peter J Gergen³⁵

Affiliations

¹ University Hospital, Montpellier and INSERM U1018, Villejuif, France. Electronic address: jean.bousquet@inserm.fr.
² University of Wisconsin School of Medicine and Public Health, Madison, Wis.
³ Arizona Respiratory Center, University of Arizona, Tucson, Ariz.
⁴ Centre for Research in Environmental Epidemiology (CREAL) and IMIM (Hospital del Mar Research Institute) and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain.
⁵ Department of Public Health Sciences, Henry Ford Health System, Detroit, Mich.
⁶ Telethon Institute for Child Health Research, University of Western Australia, and Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia.
⁷ School of Paediatrics and Child Health, Princess Margaret Hospital for Children, University of Western Australia, Perth, Australia.
⁸ Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Ind.
⁹ Dr. von Hauner Children's Hospital of the University of Munich, Munich, Germany.
¹⁰ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and the David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom.
¹¹ Washington University and St Louis Children's Hospital, St Louis, Mo.
¹² Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
¹³ Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, School of Medicine, New Haven, Conn.
¹⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹⁵ Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹⁶ Departments of Pediatrics, Epidemiology & Biostatistics, the University of California, San Francisco, Calif.
¹⁷ Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.
¹⁸ Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo.
¹⁹ Liverpool School of Tropical Medicine, Liverpool, and Escuela de Biologia, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador.
²⁰ Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Mass.
²¹ Channing Division of Network Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, and Harvard School of Public Health, Department of Environmental Health, Boston, Mass.
²² School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom.
²³ Helmholtz Zentrum, Muenchen, German Center for Environmental Health, Institute of Epidemiology I, Munich, Germany.
²⁴ Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
²⁵ Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitaetsmedizin Berlin, Berlin, and Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
²⁶ Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
²⁷ Oslo University Hospital and University of Oslo, Oslo, Norway.
²⁸ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University, New York, NY.
²⁹ Department of Public Health and Biostatistics, Paris Descartes University, Sorbonne, and Paris Municipal Department of Social Action, Childhood, and Health, Paris, France.
³⁰ Department of Pediatrics, University of Arizona, Tucson, Ariz.
³¹ Division of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Md.
³² Georgia Regents University, Augusta, Ga.
³³ Centre for Research in Environmental Epidemiology (CREAL) and IMIM (Hospital del Mar Research Institute) and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
³⁴ Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
³⁵ Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
³⁶ Department of Medicine, AstraZeneca Chair in Respiratory Epidemiology, McMaster University, Hamilton, Ontario, Canada.
³⁷ Centre for Respiratory and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester and University Hospital of South Manchester, Manchester, United Kingdom.
³⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁹ Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
⁴⁰ Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
⁴¹ Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
⁴² Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
⁴³ Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
⁴⁴ Arizona Respiratory Center and the Department of Pediatrics, University of Arizona College of Medicine, Tucson, Ariz.
⁴⁵ Department of Pediatrics and Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 24636091
PMCID: PMC4088262
DOI: 10.1016/j.jaci.2014.01.018

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Jean Bousquet et al. J Allergy Clin Immunol. 2014 Jun.

. 2014 Jun;133(6):1535-46.

doi: 10.1016/j.jaci.2014.01.018. Epub 2014 Mar 15.

Authors

Affiliations

¹ University Hospital, Montpellier and INSERM U1018, Villejuif, France. Electronic address: jean.bousquet@inserm.fr.
² University of Wisconsin School of Medicine and Public Health, Madison, Wis.
³ Arizona Respiratory Center, University of Arizona, Tucson, Ariz.
⁴ Centre for Research in Environmental Epidemiology (CREAL) and IMIM (Hospital del Mar Research Institute) and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain.
⁵ Department of Public Health Sciences, Henry Ford Health System, Detroit, Mich.
⁶ Telethon Institute for Child Health Research, University of Western Australia, and Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia.
⁷ School of Paediatrics and Child Health, Princess Margaret Hospital for Children, University of Western Australia, Perth, Australia.
⁸ Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Ind.
⁹ Dr. von Hauner Children's Hospital of the University of Munich, Munich, Germany.
¹⁰ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and the David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom.
¹¹ Washington University and St Louis Children's Hospital, St Louis, Mo.
¹² Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
¹³ Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, School of Medicine, New Haven, Conn.
¹⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹⁵ Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹⁶ Departments of Pediatrics, Epidemiology & Biostatistics, the University of California, San Francisco, Calif.
¹⁷ Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.
¹⁸ Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo.
¹⁹ Liverpool School of Tropical Medicine, Liverpool, and Escuela de Biologia, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador.
²⁰ Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Mass.
²¹ Channing Division of Network Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, and Harvard School of Public Health, Department of Environmental Health, Boston, Mass.
²² School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom.
²³ Helmholtz Zentrum, Muenchen, German Center for Environmental Health, Institute of Epidemiology I, Munich, Germany.
²⁴ Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
²⁵ Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitaetsmedizin Berlin, Berlin, and Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
²⁶ Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
²⁷ Oslo University Hospital and University of Oslo, Oslo, Norway.
²⁸ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University, New York, NY.
²⁹ Department of Public Health and Biostatistics, Paris Descartes University, Sorbonne, and Paris Municipal Department of Social Action, Childhood, and Health, Paris, France.
³⁰ Department of Pediatrics, University of Arizona, Tucson, Ariz.
³¹ Division of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Md.
³² Georgia Regents University, Augusta, Ga.
³³ Centre for Research in Environmental Epidemiology (CREAL) and IMIM (Hospital del Mar Research Institute) and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
³⁴ Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
³⁵ Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
³⁶ Department of Medicine, AstraZeneca Chair in Respiratory Epidemiology, McMaster University, Hamilton, Ontario, Canada.
³⁷ Centre for Respiratory and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester and University Hospital of South Manchester, Manchester, United Kingdom.
³⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁹ Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
⁴⁰ Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
⁴¹ Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
⁴² Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
⁴³ Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
⁴⁴ Arizona Respiratory Center and the Department of Pediatrics, University of Arizona College of Medicine, Tucson, Ariz.
⁴⁵ Department of Pediatrics and Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 24636091
PMCID: PMC4088262
DOI: 10.1016/j.jaci.2014.01.018

Abstract

Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. More than 130 birth cohorts focusing on asthma and allergy have been initiated in the last 30 years. A National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Mechanisms of the Development of Allergy (MeDALL; Framework Programme 7 of the European Commission) joint workshop was held in Bethesda, Maryland, on September 11-12, 2012, with 3 objectives: (1) documenting the knowledge that asthma/allergy birth cohorts have provided, (2) identifying the knowledge gaps and inconsistencies, and (3) developing strategies for moving forward, including potential new study designs and the harmonization of existing asthma birth cohort data. The meeting was organized around the presentations of 5 distinct workgroups: (1) clinical phenotypes, (2) risk factors, (3) immune development of asthma and allergy, (4) pulmonary development, and (5) harmonization of existing birth cohorts. This article presents the workgroup reports and provides Web links (AsthmaBirthCohorts.niaid.nih.gov or www.medall-fp7.eu), where the reader will find tables describing the characteristics of the birth cohorts included in this report, the type of data collected at differing ages, and a selected bibliography provided by the participating birth cohorts.

Keywords: Allergy; Mechanisms of the Development of Allergy (MeDALL); National Heart, Lung, and Blood Institute (NHLBI); National Institute of Allergy and Infectious Disease (NIAID); asthma; birth cohorts.

Published by Mosby, Inc.

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References

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Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Affiliations

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical