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Meta-Analysis
. 2014 Mar 17:14:197.
doi: 10.1186/1471-2407-14-197.

Tea consumption and the risk of five major cancers: a dose-response meta-analysis of prospective studies

Feifei Yu, Zhichao Jin, Hong Jiang, Chun Xiang, Jianyuan Tang, Tuo Li, Jia He  1
Affiliations
Meta-Analysis

Tea consumption and the risk of five major cancers: a dose-response meta-analysis of prospective studies

Feifei Yu et al. BMC Cancer. .

Abstract

Background: We conducted a dose-response meta-analysis of prospective studies to summarize evidence of the association between tea consumption and the risk of breast, colorectal, liver, prostate, and stomach cancer.

Methods: We searched PubMed and two other databases. Prospective studies that reported risk ratios (RRs) with 95% confidence intervals (CIs) of cancer risk for ≥3 categories of tea consumption were included. We estimated an overall RR with 95% CI for an increase of three cups/day of tea consumption, and, usingrestricted cubic splines, we examined a nonlinear association between tea consumption and cancer risk.

Results: Forty-one prospective studies, with a total of 3,027,702 participants and 49,103 cancer cases, were included. From the pooled overall RRs, no inverse association between tea consumption and risk of five major cancers was observed. However, subgroup analysis showed that increase in consumption of three cups of black tea per day was a significant risk factor for breast cancer (RR, 1.18; 95% CI, 1.05-1.32).

Conclusion: Ourresults did not show a protective role of tea in five major cancers. Additional large prospective cohort studies are needed to make a convincing case for associations.

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Figures

Figure 1
Figure 1
Summary of article selection process.
Figure 2
Figure 2
Relative risk estimates of breast cancer per 3 cups increase in tea consumption.
Figure 3
Figure 3
Relative risk estimates of colorectal cancer per 3 cups increase in tea consumption.
Figure 4
Figure 4
Relative risk estimates of liver cancer per 3 cups increase in tea consumption.
Figure 5
Figure 5
Relative risk estimates of prostate cancer per 3 cups increase in tea consumption.
Figure 6
Figure 6
Relative risk estimates of stomach cancer per 3 cups increase in tea consumption.
Figure 7
Figure 7
Dose–response relations between tea consumption and relative risks of breast, colorectal, stomach, prostate cancer.
Figure 8
Figure 8
Funnel plot of log relative risk vs standard error of log relative risks.
See this image and copyright information in PMC

References

    1. Food and Agriculture Organization of the United Nations. Food balance sheets, 1994–1996. Available from: http://faostat3.fao.org/home/index.html#DOWNLOAD_STANDARD.
    1. Shimizu M, Adachi S, Masuda M, Kozawa O, Moriwaki H. Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Mol Nutr Food Res. 2011;55(6):832–843. doi: 10.1002/mnfr.201000622. - DOI - PubMed
    1. Suzuki Y, Miyoshi N, Isemura M. Health-promoting effects of green tea. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(3):88–101. doi: 10.2183/pjab.88.88. - DOI - PMC - PubMed
    1. Ahmad N, Mukhtar H. Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev. 1999;57(3):78–83. - PubMed
    1. Lambert JD. Does tea prevent cancer? Evidence from laboratory and human intervention studies. Am J Clin Nutr. 2013;98(6):1667S–1675S. doi: 10.3945/ajcn.113.059352. - DOI - PubMed

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