Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;18(2):125-31.
doi: 10.1016/j.canrad.2014.02.003. Epub 2014 Mar 14.

[Radiation therapy of cardiac sarcomas]

[Article in French]
Affiliations

[Radiation therapy of cardiac sarcomas]

[Article in French]
J Thariat et al. Cancer Radiother. 2014 Mar.

Abstract

Purpose: Primary cardiac sarcomas represent less than 10 yearly cases in France. Their median survival is approximately 18 months. The treatment consists of surgery when possible. The role of chemotherapy and radiation therapy is controversial, especially with respect to limiting cardiac radiation dose that is theoretically incompatible with the requirement of a tumoricidal dose for sarcoma. A recent series of 124 cases of the French Sarcoma Group suggested a benefit of radiation therapy on progression-free survival.

Patients and methods: The dosimetric data of 12 patients were analyzed.

Results: There was variety in radiotherapy modalities and definition of target volumes, doses and techniques are evolving more conformal plans. Irradiation appeared feasible with conventional fractionation with respect to toxicities (although probably underestimated due to short follow-up and dismal prognosis) and previously demonstrated benefit of radiotherapy for primitive cardiac sarcomas.

Conclusion: A scheme of 45Gy in 1.8Gy per fraction to a preoperative volume with an additional dose of 14Gy in 7 fractions on areas at risk or residual disease and margins 1cm, may be proposed based on the preliminary data of this study. Intensity modulated radiotherapy with daily cone-beam CT-scanner should be evaluated.

Keywords: Cardiac; Cardiaque; Cœur; Dose; Heart; Radiotherapy; Radiothérapie; Sarcoma; Sarcome; Target volumes; Toxicity; Toxicité; Volumes cibles.

PubMed Disclaimer

Publication types

LinkOut - more resources