Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2014;6(1):16-21.
doi: 10.4274/Jcrpe.1220.

Urinary bisphenol a levels in girls with idiopathic central precocious puberty

Erdem Durmaz  1 , Ali Aşçı, Pınar Erkekoğlu, Sema Akçurin, Belma Koçer Gümüşel, Iffet Bircan
Affiliations
Comparative Study

Urinary bisphenol a levels in girls with idiopathic central precocious puberty

Erdem Durmaz et al. J Clin Res Pediatr Endocrinol. 2014.

Abstract

Objective: Bisphenol A (BPA) is an industrial chemical, particularly used to harden plastics. BPA is thought to have negative health effects on both laboratory animals and humans. Consider ing the decline in age of onset of puberty noted in recent years, particularly among girls, the importance of BPA as an estrogenic endocrine disruptor has increased. In this study, we aimed to determine urinary BPA levels in girls with idiopathic central precocious puberty (ICPP).

Methods: Non-obese girls newly diagnosed with ICPP (n=28, age 4-8 years) constituted the study group. The control group consisted of 25 healthy age-matched girls with no history of ICPP or any other endocrine disorder. Urinary BPA levels were measured by using high-performance liquid chromatography.

Results: In the ICPP group, urinary BPA levels were significantly higher compared to the control group [median 8.34 (0.84-67.35) μg/g creatinine and 1.62 (0.3-25.79) μg/g creatinine, respectively (OR=8.68, 95% CI:2.03-32.72, p=0.001)]. There was no marked correlation between urinary BPA levels and body mass index in either group. In the ICPP group, no significant correlations were found between urinary BPA levels and serum luteinizing hormone, follicle-stimulating hormone and estradiol levels.

Conclusions: To our knowledge, this is the first study evaluating the urinary BPA levels in Turkish girls with ICPP. Our results indicate that the estrogenic effects of BPA may be an etiologic factor in ICPP.

PubMed Disclaimer

Figures

Figure 1
Figure 1. High-performance liquid chromatography (HPLC) chromatogram of bisphenol A (BPA) standards. Calculations were made according to the peak heights. Retention times were between 18.3-19.2 minutes
Figure 2
Figure 2. The distribution of urinary bisphenol A (BPA) levels in idiopathic central precocious puberty (ICPP) subjects and controls
See this image and copyright information in PMC

References

    1. Lebrethon MC, Bourguignon JP. Management of central isosexual precocity: diagnosis, treatment, outcome. Curr Opin Pediatr. 2000;12:394–399. - PubMed
    1. Bridges NA, Christopher JA, Hindmarsh PC, Brook CG. Sexual precocity: sex incidence and aetiology. Arch Dis Child. 1994;70:116–118. - PMC - PubMed
    1. Main KM, Skakkebaek NE, Juul A. Hypothesis: exposure to endocrine disrupting chemicals may interfere with timing of puberty. Int J Androl. 2010;33:346–359. - PubMed
    1. Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sørensen TI, Dunkel L, Himes JH, Teilmann G, Swan SH. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics. 2008;121(Suppl 3):172–191. - PubMed
    1. Biro FM, Galvez MP, Greenspan LC, Succop PA, Vangeepuram N, Windham GC, Kushi LH, Wolff MS. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics. 2010;126:583–590. - PMC - PubMed

Publication types

LinkOut - more resources