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. 1988 Jul 14;151(3):491-5.
doi: 10.1016/0014-2999(88)90550-x.

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

J A Peters  1 , T G Hales, J J Lambert
Affiliations

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

J A Peters et al. Eur J Pharmacol. .

Abstract

The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

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