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. 2014 May;90(5):852-5.
doi: 10.4269/ajtmh.13-0550. Epub 2014 Mar 17.

Comprehensive sterilization of malaria vectors using pyriproxyfen: a step closer to malaria elimination

Dickson W Lwetoijera  1 , Caroline Harris, Samson S Kiware, Gerry F Killeen, Stefan Dongus, Gregor J Devine, Silas Majambere
Affiliations

Comprehensive sterilization of malaria vectors using pyriproxyfen: a step closer to malaria elimination

Dickson W Lwetoijera et al. Am J Trop Med Hyg. 2014 May.

Abstract

One of the main challenges to malaria elimination is the resilience of vectors, such as Anopheles arabiensis, that evade lethal exposure to insecticidal control measures or express resistance to their active ingredients. This study investigated a novel technology for population control that sterilizes mosquitoes using pyriproxyfen, a juvenile hormone analogue. Females of An. arabiensis were released in a semifield system divided into four equal sections, and each section had a mud hut sheltering a tethered cow providing a blood source for mosquitoes. In all sections, the inner mud hut walls and roofs were lined with black cotton cloth. In one-half of the sections, the cloth was dusted with pyriproxyfen. An overwhelming 96% reduction in adult production was achieved in pyriproxyfen-treated sections compared with control sections. This unprecedented level of control can be exploited to design new vector control strategies that particularly target existing behaviorally resilient and insecticide-resistant populations.

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Figures

Figure 1.
Figure 1.
Semifield system (SFS) setup. (A) SFS with (B) mud huts built inside each section to shelter a cow and (C) breeding habitats. (D) Mud huts were lined with black cloth and dusted with PPF in treatment sections.
Figure 2.
Figure 2.
Impact of PPF on mosquito emergence. Number of (A) pupae produced and (B) adults emerging from control and treated sections and the proportion of adult emergence in (C) SFS and (D) insectary bioassays.
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