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. 2013 Feb;11(2):133-8.

Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial

Maryam Eftekhar  1 , Elham Rahmani  2 , Farnaz Mohammadian  3
Affiliations

Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial

Maryam Eftekhar et al. Iran J Reprod Med. 2013 Feb.

Abstract

Background: Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits.

Objective: To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART protocols.

Materials and methods: In a prospective randomized study, one hundred women who underwent ART cycles were randomly divided into two groups. In group I, the patients received one single injection of 1.87 mg Triptorelin in previous mid-luteal phase. In group II, Decapeptyl 0.1 mg per day started from previous mid-luteal phase. Pregnancy outcome in in vitro fertilization (IVF) cycle was compared between two groups.

Results: There were no statistically significant differences in the number of retrieved oocyte (p=0.545), fertilization (p=0.876), implantation (p=0.716) and pregnancy rate (p=0.727) between the two groups.

Conclusion: There were not any advantages in IVF outcome between half-dose long-acting and short-acting GnRH agonist groups in ART cycle.

Keywords: Decapeptyl; GnRH agonist; In vitro fertilization; Infertility; Pregnancy outcome.

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Figures

Figure 1
Figure 1
Consort flow diagram
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References

    1. Dal Prato L, Borini A, Coticchio G, Cattoli M, Flamigni C. Half-dose depot triptorelin in pituitary suppression for multiple ovarian stimulation in assisted reproduction technology: a randomized study. Hum Reprod. 2004;19:2200–2205. - PubMed
    1. Yim SF, Lok IH, Cheung LP, Briton-Jones CM, Chiu TTY, Haines CJ. Dose-finding study for the use of long-acting gonadotrophin-releasing hormone analogues prior to ovarian stimulation for IVF. Hum Reprod. 2001;16:492–494. - PubMed
    1. Hsieh YY, Chang CC, Tsai HD. Comparisons of Different Dosages of Gonadotropin-releasing hormone (GnRH) antagonist, short-acting form and single, half-dose, long-acting form of GnRH agonist during controlled ovarian hyperstimulation and in vitro fertilization. Taiwan J Obstet Gynecol. 2008;47:66–74. - PubMed
    1. Isikoglu M, Ozdem S, Berkkanoglu M, Jamal H, Senturk Z, Ozgur K. Single-dose depot leuprolide is as efficient as daily short-acting leuprolide in ICSI cycles. Hum Reprod. 2007;22:1657–1661. - PubMed
    1. Cheon KW, Song SJ, Choi BC, Lee SC, Lee HB, Yu SY, et al. Comparison of clinical efficacy between a single administration of long-acting gonadotrophin-releasing hormone agonist (GnRHa) and daily administrations of short-acting GnRHa in in vitro fertilization-embryo transfer cycles. J Korean Med Sci. 2008;23:662–666. - PMC - PubMed