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. 2013 Aug;11(8):647-52.

Survey of predictive value of 4-hour urine collection for diagnosis of proteinuria in preeclampsia

Maryam Asgharnia  1 , Roya Faraji  1 , Nooshaz Mirhaghjoo  2 , Zahra Atrkar Roshan  3 , Babak Ashrafkhani  4 , Mina Moslehi  1
Affiliations

Survey of predictive value of 4-hour urine collection for diagnosis of proteinuria in preeclampsia

Maryam Asgharnia et al. Iran J Reprod Med. 2013 Aug.

Abstract

Background: Measuring the 24-hour urine protein ≥300 mg is the standard threshold value for diagnosis of preeclampsia.

Objective: This study was intended to determine if a patient's 4-hour urine protein correlate with the 24-hour value for diagnosis of preeclampsia.

Materials and methods: This was a cross sectional study performed on 84 women with suspected preeclampsia due to positive urinary test strip with minimum protein content of 1+ and BP ≥140/90 at Al-zahra Educational Hospital in Rasht (Iran) from May 2007 to January 2008. Urine samples were collected within 24 hours in successive periods: The first 4-hour and the next 20-hours urine, in separate containers. The protein contents of 4-hour and 24-hour urine samples were calculated. Data were analyzed by intra-class correlation coefficient, and Receiver Operating Characteristic (ROC) curve.

Results: The ROC curve showed the cut-off point of 55.5 for 4-hour urine protein. The correlation between 4- and 24-hour urine protein excretions identified that most women (about 85.1%) with protein excretion rate of 300 mg/24h or more (with preeclampsia) had the same amount of protein of 55.5 or more in their 4-hour urine excretion (p<0.001). Also, most of them (about 83.7%) with a total urinary protein excretion of less than 300 mg/24h (no preeclampsia) had a protein excretion rate of less than 55.5 mg/4h.

Conclusion: This study showed 4-hour protein collection can be used as acceptable substitute for assessing the protein content of 24-hour urine samples as a more convenient, faster, and cheaper method for diagnosis of preeclampsia and the cut-off point for 4-hour urine protein is 55.5 mg. This article extracted from a submitted thesis. (Mina Moslehi).

Keywords: Gestationalhypertension; Preeclampsia; Proteinuria.

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Figures

Figure 1
Figure 1
Predictive values of 4-hour urinary protein excretion for detection of significant proteinuria with various cut offs. The ROC curve showed the cut-off point of 55.5 for 4-hour urine protein.
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