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. 2013 Mar 25:Suppl 1:001.
doi: 10.4172/2161-0460.S1-001.

Magnetic Resonance Imaging (MRI) in Parkinson's Disease

Paul J Tuite  1 , Silvia Mangia  2 , Shalom Michaeli  2
Affiliations

Magnetic Resonance Imaging (MRI) in Parkinson's Disease

Paul J Tuite et al. J Alzheimers Dis Parkinsonism. .

Abstract

Recent developments in brain imaging methods are on the verge of changing the evaluation of people with Parkinson's disease (PD). This includes an assortment of techniques ranging from diffusion tensor imaging (DTI) to iron-sensitive methods such as T2*, as well as adiabatic methods R1ρ and R2ρ, resting-state functional MRI, and magnetic resonance spectroscopy (MRS). Using a multi-modality approach that ascertains different aspects of the pathophysiology or pathology of PD, it may be possible to better characterize disease phenotypes as well as provide a surrogate of disease and a potential means to track disease progression.

Keywords: Adiabatic methods R1ρ and R2ρ; Diffusion Tensor Imaging (DTI); Magnetic Resonance Spectroscopy (MRS); Magnetization transfer imaging (MTI); Relaxations along a Fictitious Field (RAFF); Resting-state MRI; Susceptibility-weighted imaging (SWI); T2*; Voxel-based morphometry (VBM).

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Figures

Figure 1
Figure 1
Susceptibility weighted imaging (SWI) acquired at a high-field (7T) MRI. Image resolutions 0.4 × 0.4 × 0.8 mm3. The axial image at the levels of the substantia nigra (SN) level. Images courtesy of Dr. Noam Harel, University of Minnesota.
Figure 2
Figure 2
Susceptibility weighted imaging (SWI) acquired at a high-field (7T) MRI. Image resolutions 0.4 × 0.4 × 0.8 mm3. Coronal view shows a clear delineation between the subthalamic nucleus (STN) (higher arrow) and the substantia nigra (lower arrow). Images courtesy of Dr. Noam Harel, University of Minnesota.
Figure 3
Figure 3
Rotating frame R1ρ maps (middle column), MT rate maps (R1sat) (right column), with relative T2-weighted (T2w) images (left column) from representative control subject (top row) and PD patient (bottom row). Regions of interest (ROIs) – as depicted on T2w images – were obtained in maps from six areas: (1) medial raphe nucleus; (2) dorsal raphe nucleus; (3) nucleus raphe pontis; (4) nucleus raphe magnus; (5) nucleus raphe pallidus; (6) nucleus raphe obscuris [23].
Figure 4
Figure 4
GABA concentrations in pons and putamen in individuals with Parkinson’s disease (PD) and controls; together with means (boxes) and standard deviations (error bars) [37].
See this image and copyright information in PMC

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