doi: 10.1111/bph.12617.
GABAB receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006
Affiliations
- PMID: 24641323
- PMCID: PMC4562517
- DOI: 10.1111/bph.12617
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GABAB receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006
Br J Pharmacol.
2015 Sep.
Abstract
This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M and Poli S (2014). ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol 171: 995-1006. doi: 10.1111/bph.12517.
Keywords: GABAB receptor; bladder pain syndrome; colon; gastrointestinal; irritable bowel syndrome; motility; positive allosteric modulator; visceral hypersensitivity.
© 2015 The British Pharmacological Society.
Comment on
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ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.Br J Pharmacol. 2014 Feb;171(4):995-1006. doi: 10.1111/bph.12517. Br J Pharmacol. 2014. PMID: 24224799 Free PMC article.
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