Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jun:30:174-80.
doi: 10.1016/j.semcdb.2014.03.013. Epub 2014 Mar 15.

Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

S Champeris Tsaniras  1 , N Kanellakis  2 , I E Symeonidou  3 , P Nikolopoulou  4 , Z Lygerou  5 , S Taraviras  6
Affiliations
Free article
Review

Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

S Champeris Tsaniras et al. Semin Cell Dev Biol. 2014 Jun.
Free article

Abstract

Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer.

Keywords: Cancer; DNA replication; Development; Licensing; Origin specification; Pluripotency.

PubMed Disclaimer

Publication types

LinkOut - more resources