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. 2014 Nov;21(11):1423-7.
doi: 10.1177/1933719114527354. Epub 2014 Mar 18.

The common single-nucleotide polymorphism rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women

Ji-Peng Wan  1 , Hong Wang  1 , Chang-Zhong Li  1 , Han Zhao  2 , Li You  2 , Dong-Hong Shi  1 , Xiu-Hua Sun  3 , Hong Lv  1 , Fei Wang  1 , Ze-Qing Wen  1 , Xie-Tong Wang  4 , Zi-Jiang Chen  2
Affiliations

The common single-nucleotide polymorphism rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women

Ji-Peng Wan et al. Reprod Sci. 2014 Nov.

Abstract

Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.

Keywords: ATP2B1; genetics; polymorphisms; preeclampsia.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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