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. 2012 Spring;6(1):26-32.

Comparison of Two brands of Methylphenidate (Stimdate(®) vs. Ritalin(®)) in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial

Naser Khodadust  1 , Amir-Hossein Jalali  2 , Masoud Ahmadzad-Asl  3 , Noushin Khademolreza  1 , Elham Shirazi  2
Affiliations

Comparison of Two brands of Methylphenidate (Stimdate(®) vs. Ritalin(®)) in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial

Naser Khodadust et al. Iran J Psychiatry Behav Sci. 2012 Spring.

Abstract

Objective: To compare the effectiveness and safety of the methylphenidate produced in Iran (Stimdate®) with its original brand (Ritalin®) in children with Attention deficit hyperactivity disorder (ADHD).

Methods: In this double-blinded randomized clinical trial, 30 patients with ADHD who were 6 to 16 years old, were divided into two groups: 15 in Stimdate® and 15 in Ritalin® group. The two groups were compared for side effects profile, Conner's Parent's Rating Scale-Persion version (CPRS-R), Child Symptom Inventory-4 (CSI-4), Clinical Global Impressions (CGI), and Children's Global Assessment Scale (CGAS), at baseline and at the 4(th) and 6(th) weeks.

Results: The subjects showed significant decreases in the CPRS-Rand CSI-4 scores and significant increase of CGAS scores during the follow-up, but there were no significant difference between Stimdate® and Ritalin® group, regarding the pattern of changes observed. The mean therapeutic dose and the number of side effects were not significantly different between the two studied groups.

Conclusions: Both Stimdate® and Ritalin® had comparable clinical efficacy and safety in children with ADHD.

Keywords: ADHD; Ritalin; Side effects; Stimdate; Therapeutic effect.

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Figures

Figure 1
Figure 1
Changes in CPRS-R, CSI, and CGAS during follow up in Ritalin® and Stimdate® groups
See this image and copyright information in PMC

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