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. 2014 Dec;29(12):1692-8.
doi: 10.1177/0883073813513335. Epub 2014 Mar 18.

Systemic inflammation and cerebral palsy risk in extremely preterm infants

Karl C K Kuban  1 , T Michael O'Shea  2 , Elizabeth N Allred  3 , Nigel Paneth  4 , Deborah Hirtz  5 , Raina N Fichorova  6 , Alan Leviton  7 ; ELGAN Study Investigators
Collaborators, Affiliations

Systemic inflammation and cerebral palsy risk in extremely preterm infants

Karl C K Kuban et al. J Child Neurol. 2014 Dec.

Abstract

The authors hypothesized that among extremely preterm infants, elevated concentrations of inflammation-related proteins in neonatal blood are associated with cerebral palsy at 24 months. In 939 infants born before 28 weeks gestation, the authors measured blood concentrations of 25 proteins on postnatal days 1, 7, and 14 and evaluated associations between elevated protein concentrations and cerebral palsy diagnosis. Protein elevations within 3 days of birth were not associated with cerebral palsy. Elevations of tumor necrosis factor-α, tumor necrosis factor-α-receptor-1, interleukin-8, and intercellular adhesion molecule-1 on at least 2 days were associated with diparesis. Recurrent-persistent elevations of interleukin-6, E-selectin, or insulin-like growth factor binding protein-1 were associated with hemiparesis. Diparesis and hemiparesis were more likely among infants who had at least 4 of 9 protein elevations that previously have been associated with cognitive impairment and microcephaly. Repeated elevations of inflammation-related proteins during the first 2 postnatal weeks are associated with increased risk of cerebral palsy.

Keywords: cerebral palsy risk; inflammation.

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References

    1. Yoon BH, Romero R, Yang SH, et al. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. American journal of obstetrics and gynecology. 1996;174(5):1433–1440. - PubMed
    1. Minagawa K, Tsuji Y, Ueda H, et al. Possible correlation between high levels of IL-18 in the cord blood of pre-term infants and neonatal development of periventricular leukomalacia and cerebral palsy. Cytokine. 2002;17(3):164–170. - PubMed
    1. Hansen-Pupp I, Harling S, Berg A-C, Cilio C, Hellstrom-Westas L, Ley D. Circulating interferon-gamma and white matter brain damage in preterm infants. Pediatric research. 2005;58(5):946–952. - PubMed
    1. Hansen-Pupp I, Hallin A-L, Hellstrom-Westas L, et al. Inflammation at birth is associated with subnormal development in very preterm infants. Pediatric research. 2008;64(2):183–188. - PubMed
    1. Kaukola T, Satyaraj E, Patel DD, et al. Cerebral palsy is characterized by protein mediators in cord serum. Annals of neurology. 2004 Feb;55(2):186–194. - PubMed

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