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. 1988 Aug;36(4):347-51.

[Alpha-fetoprotein and trisomy 21]

[Article in French]
S Guibaud  1 , C Boisson, A Simplot, J M Thoulon, J P Favier, P Guibaud, J M Robert
Affiliations
  • PMID: 2464665

[Alpha-fetoprotein and trisomy 21]

[Article in French]
S Guibaud et al. J Genet Hum. 1988 Aug.

Abstract

In 31 affected pregnancies with Down syndrome, the median maternal serum alpha-fetoprotein value was lower than normal, 0.76 MoM, and median amniotic fluid value was quite normal, 0.98 MoM. Selecting an arbitrary cutoff-point of 0.5 MoM, 4.1 percent of normal gestations show values less than 0.5 MoM. Authors discuss problems about screening for fetal Down's syndrome by measuring maternal serum AFP levels.

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