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. 2014 May 27;97(10):1079-85.
doi: 10.1097/01.TP.0000438619.96933.02.

Preoperative mild-to-moderate coronary artery disease does not affect long-term outcomes of lung transplantation

Giorgio Zanotti  1 , Matthew G Hartwig, Anthony W Castleberry, Jeremiah T Martin, Linda K Shaw, Judson B Williams, Shu S Lin, Robert D Davis
Affiliations

Preoperative mild-to-moderate coronary artery disease does not affect long-term outcomes of lung transplantation

Giorgio Zanotti et al. Transplantation. .

Erratum in

  • Transplantation. 2015 Feb;99(2):e15

Abstract

Background: Coronary artery disease has a high prevalence among lung transplant recipients and has historically been a contraindication to transplant at many institutions. In patients with mild-to-moderate coronary artery disease (Mod-CAD) undergoing lung transplant, outcomes are not well defined.

Methods: All patients who underwent pulmonary transplantation from January 1996 through November 2010 with pretransplant coronary angiogram were included in our study. Recipients of multivisceral, redo, and lobar lung transplants and those who underwent pretransplant coronary revascularization were excluded. Patients were grouped into Mod-CAD or no-coronary artery disease group (No-CAD). Primary end point was overall survival. Secondary end points were 30-day events and the need for posttransplant coronary revascularization.

Results: Approximately 539 patients were included in the study: 362 in the No-CAD, 177 in the Mod-CAD group. Patients with Mod-CAD were predominantly male, older, and had a higher body mass index. No difference in either perioperative morbidity and mortality (Mod-CAD, 4.2% vs. No-CAD 3.3%, P=0.705) or late overall mortality was shown between groups. Mod-CAD patients had a shorter hospitalization (median: 12 days vs. 14 days, P=0.009) and required a higher rate of late coronary revascularization procedures (PCI: Mod-CAD vs. No-CAD, 0.3% vs. 4.0%, P=0.0035; CABG: Mod-CAD vs. No-CAD, 0.3% vs. 2.3%, P=0.0411).

Conclusions: Mod-CAD does not appear to be associated with increased perioperative morbidity or decreased survival after transplant. Coronary artery disease may worsen and require coronary revascularization in patients with risk factors for disease progression. In these patients, close follow-up and screening for progression of coronary artery disease may help prevent late cardiac morbidity.

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References

    1. Reed RM, Eberlein M, Girgis RE, et al. Coronary artery disease is under-diagnosed and under-treated in advanced lung disease. Am J Med. 2012;125:1228. e13. - PMC - PubMed
    1. Choong CK, Meyers BF, Guthrie TJ, et al. Does the presence of pre-operative mild or moderate coronary artery disease affect the outcomes of lung transplantation? Ann Thorac Surg. 2006;82:1038. - PubMed
    1. Sherman W, Rabkin DG, Ross D, et al. Lung transplantation and coronary artery disease. Ann Thorac Surg. 2011;92:303. - PubMed
    1. Christie JD, Edwards LB, Kucheryavaya AY, et al. The registry of the international society for heart and lung transplantation: 29th adult lung and heart-lung transplant report-2012. J Heart Lung Transplant. 2012;31:1073. - PubMed
    1. Patel VS, Palmer SM, Messier RH, et al. Clinical outcome after coronary artery revascularization and lung transplantation. Ann Thorac Surg. 2003;75:372. discussion 377. - PubMed

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