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. 1989 Mar;63(3):1408-12.
doi: 10.1128/JVI.63.3.1408-1412.1989.

Amino acid sequence of a conserved neutralizing epitope of murine coronaviruses

W Luytjes  1 , D Geerts, W Posthumus, R Meloen, W Spaan
Affiliations

Amino acid sequence of a conserved neutralizing epitope of murine coronaviruses

W Luytjes et al. J Virol. 1989 Mar.

Abstract

We identified the binding site of monoclonal antibody 19.2, which cross-neutralizes several mouse hepatitis virus (MHV) strains, inhibits fusion of MHV-infected cells, and protects against lethal infection (P. J. Talbot and M. J. Buchmeier, Virus Res. 2:317-328, 1985). We used fusion proteins, generated by expression of fragments of the MHV A59 E2 gene in pEX plasmids, and synthetic peptides in a PEPSCAN.

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References

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