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Review
. 2014 Jun;16(6):511-6.
doi: 10.1007/s12094-014-1162-1. Epub 2014 Mar 20.

Cancer cell resistance mechanisms: a mini review

S Al-Dimassi  1 , T Abou-Antoun, M El-Sibai
Affiliations
Review

Cancer cell resistance mechanisms: a mini review

S Al-Dimassi et al. Clin Transl Oncol. 2014 Jun.

Abstract

Cancer is a leading cause of death worldwide accounting to 13 % of all deaths. One of the main causes behind the failure of treatment is the development of various therapy resistance mechanisms by the cancer cells leading to the recurrence of the disease. This review sheds a light on some of the mechanisms developed by cancer cells to resist therapy as well as some of the structures involved such as the ABC members' involvement in chemotherapy resistance and MET and survivin overexpression leading to radiotherapy resistance. Understanding those mechanisms will enable scientists to overcome resistance and possibly improve treatment and disease prognosis.

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