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. 2014 Jun;52(6):2172-4.
doi: 10.1128/JCM.00189-14. Epub 2014 Mar 19.

Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting

George Sakoulas  1 , Kripa Guram  2 , Katherine Reyes  3 , Victor Nizet  2 , Marcus Zervos  3
Affiliations

Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting

George Sakoulas et al. J Clin Microbiol. 2014 Jun.

Abstract

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.

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Figures

FIG 1
FIG 1
LL-37 (16 μM) killing of MRSA bloodstream isolates at 90 min, stratified by USA600 versus other MRSA isolates (A) or daptomycin MIC (B). USA600 was more resistant to killing (P < 0.0001, Mann-Whitney U test), and MRSA isolates with a daptomycin MIC of ≥0.5 were significantly more resistant to killing (P < 0.001, Mann-Whitney U test). (C) Daptomycin MIC distribution of MRSA bloodstream isolates demonstrating an increased MIC distribution among USA600 versus other MRSA strains (P < 0.01, Mann-Whitney U test). Horizontal lines denote the mean value for the population.
See this image and copyright information in PMC

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