Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;55(3):222-5.
doi: 10.4111/kju.2014.55.3.222. Epub 2014 Mar 13.

Metastasis of non-muscle-invasive bladder cancer into the thyroid gland: a literature review accompanied by a rare case

Murat Tuncer  1 , Gokhan Faydaci  1 , Gokhan Altin  2 , Banu Atalay Erdogan  2 , Sermin Kibar  2 , Arif Sanli  2 , Dilek Bilgici  3
Affiliations

Metastasis of non-muscle-invasive bladder cancer into the thyroid gland: a literature review accompanied by a rare case

Murat Tuncer et al. Korean J Urol. 2014 Mar.

Abstract

Bladder cancer is the most prevalent malignancy of the urinary tract. About 90% of bladder cancers are urothelial carcinomas. Seventy percent of cases newly diagnosed are superficial diseases; roughly 30% of newly diagnosed cases are muscle-invasive metastatic diseases. Bladder urothelial carcinoma primarily metastasizes into regional lymph nodes and then into liver, lung, mediastinum, bone, and adrenal gland. In our case, non-muscle-invasive bladder cancer metastasized into the bone, mediastinum, iliac lymph node, and adrenal and thyroid glands. This is the first reported case in the current literature in which urothelial carcinoma metastasized into the thyroid gland.

Keywords: Neoplasm metastasis; Thyroid gland; Urinary bladder neoplasms.

PubMed Disclaimer

Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Bladder transurethral resection biopsy: high-grade urothelial carcinoma with invasion of the lamina propria by malignant epithelial tumor cells with large, pleomorphic nuclei (H&E, ×200).
FIG. 2
FIG. 2
Costal bone biopsy: metastasis of urothelial carcinoma. Malignant epithelial tumor cells show a papillar configuration into the bone trabeculae (H&E, ×100).
FIG. 3
FIG. 3
Thyroid fine needle aspiration biopsy: groups of malignant tumor cells with large pleomorphic nuclei are shown (MGG, ×400).
See this image and copyright information in PMC

References

    1. Ferlay J, Randi G, Bosetti C, Levi F, Negri E, Boyle P, et al. Declining mortality from bladder cancer in Europe. BJU Int. 2008;101:11–19. - PubMed
    1. Dougherty DW, Gonsorcik VK, Harpster LE, Trussell JC, Drabick JJ. Superficial bladder cancer metastatic to the lungs: two case reports and review of the literature. Urology. 2009;73:210.e3–210.e5. - PubMed
    1. Alexander PW, Sanders C, Nath H. Cavitary pulmonary metastases in transitional cell carcinoma of urinary bladder. AJR Am J Roentgenol. 1990;154:493–494. - PubMed
    1. Nishiyama H, Habuchi T, Watanabe J, Teramukai S, Tada H, Ono Y, et al. Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990-2000 in Japan. Eur Urol. 2004;45:176–181. - PubMed
    1. Gwynn ES, Clark PE. Bladder cancer. Curr Opin Oncol. 2006;18:277–283. - PubMed

LinkOut - more resources