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Review
. 2013 Jul;1(4):499-505.
doi: 10.3892/br.2013.95. Epub 2013 Apr 18.

Targeted therapy in HER2-positive breast cancer

Shu Guang Li  1 , Li Li  1
Affiliations
Review

Targeted therapy in HER2-positive breast cancer

Shu Guang Li et al. Biomed Rep. 2013 Jul.

Abstract

Treatment options for breast cancer vary based on tumor surface markers and clinical factors, including cytotoxic chemotherapy, hormonal therapy, biological therapy or a combination thereof. An important molecular determinant of therapy is the human epidermal growth factor receptor 2 (HER2) positivity of the tumor, which has been identified in 20-25% of breast cancers and is a prognostic marker of poor outcome. The advent of HER2-targeted therapies has significantly improved the survival of patients with HER2-positive breast cancer. This review focuses on current HER2-targeted therapeutic options for patients with HER2-positive breast cancer, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs).

Keywords: breast cancer; human epidermal growth factor receptor 2; monoclonal antibodies; targeted therapy; tyrosine kinase inhibitors.

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