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. 2014 Mar;2(2):245-251.
doi: 10.3892/mco.2013.230. Epub 2013 Dec 20.

Clinical characteristics and prognostic analysis of triple-negative breast cancer patients

Na Yuan  1 , Min Meng  1 , Caigang Liu  2 , Lu Feng  1 , Lei Hou  1 , Qian Ning  1 , Guohong Xin  1 , Li Pei  1 , Shanzhi Gu  3 , Xiao Li  4 , Xinhan Zhao  1
Affiliations

Clinical characteristics and prognostic analysis of triple-negative breast cancer patients

Na Yuan et al. Mol Clin Oncol. 2014 Mar.

Abstract

It is well-established that triple-negative breast cancer (TNBC) is a subtype of breast cancer, characterized by a poor prognosis and aggressive biological behavior. However, the available relevant data on TNBC in non-Western populations are limited. In order to analyze the clinicopathological and molecular biological characteristics and observe survival and prognostic factors, 972 breast cancer patients (156 of whom had TNBC) who received treatment at the First Affiliated Hospital of Medical School of Xi'an Jiaotong University and the First Hospital of China Medical University, between January, 2004 and January, 2007 were retrospectively evaluated. In the univariate analysis, tumor size, TNM stage, axillary lymph node status and recurrence or metastasis were identified as prognostic factors for 7-year disease-free survival (DFS) and overall survival (OS). Our multivariate Cox's regression analysis demonstrated that tumor size and axillary lymph node status were significant prognostic factors for 7-year DFS and OS. Notably, tumor subgroup (TNBC vs. non-TNBC) was a significant prognostic factor associated with 7-year DFS and OS in breast cancer. It was suggested that TNBC exhibited a worse 7-year survival compared with that in non-TNBC patients, most likely due to its more aggressive behavior and insensitivity to specific therapy.

Keywords: clinicopathological characteristics; prognostic analysis; survival analysis; triple-negative breast cancer.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves. (A) Disease-free survival (DFS) and (B) overall survival (OS) in triple-negative breast cancer (TNBC) and non-TNBC patients. Cens., censored.
Figure 1
Figure 1
Kaplan-Meier survival curves. (A) Disease-free survival (DFS) and (B) overall survival (OS) in triple-negative breast cancer (TNBC) and non-TNBC patients. Cens., censored.
See this image and copyright information in PMC

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