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Review
. 2014:2014:321359.
doi: 10.1155/2014/321359. Epub 2014 Feb 6.

Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects

Emanuele Cozzani  1 , Massimo Drosera  1 , Giulia Gasparini  1 , Aurora Parodi  1
Affiliations
Review

Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects

Emanuele Cozzani et al. Autoimmune Dis. 2014.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies. Antibodies to ds-DNA are useful for the diagnosis of SLE, to monitor the disease activity, and correlate with renal and central nervous involvements. Anti-Sm antibodies are highly specific for SLE. Anti-nucleosome antibodies are an excellent marker for SLE and good predictors of flares in quiescent lupus. Anti-histone antibodies characterize drug-induced lupus, while anti-SSA/Ro and anti-SSB/La antibodies are associated with neonatal lupus erythematosus and photosensitivity. Anti-ribosomal P antibodies play a role in neuropsychiatric lupus, but their association with clinical manifestations is still unclear. Anti-phospholipid antibodies are associated with the anti-phospholipid syndrome, cerebral vascular disease, and neuropsychiatric lupus. Anti-C1q antibodies amplify glomerular injury, and the elevation of their titers may predict renal flares. Anti-RNP antibodies are a marker of Sharp's syndrome but can be found in SLE as well. Anti-PCNA antibodies are present in 5-10% of SLE patients especially those with arthritis and hypocomplementemia.

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Figures

Figure 1
Figure 1
IIF on Hep2 cells: homogeneous pattern. Dilution 1 : 40.
Figure 2
Figure 2
IIF on HEp2 cells: speckeld and nuclear and nucleolar staining (anti-SSA/Ro antibodies). Dilution 1 : 40.
Figure 3
Figure 3
IIF on Hep2 cells: speckled pattern (anti-RNP antibodies). Dilution 1 : 40.
Figure 4
Figure 4
IIF on Hep2 cells: speckled pattern of varying intensity (anti-PCNA antibodies). Diluition 1 : 40.
See this image and copyright information in PMC

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