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. 2014 Apr 2;136(13):4905-8.
doi: 10.1021/ja501561c. Epub 2014 Mar 24.

A switchable [2]rotaxane asymmetric organocatalyst that utilizes an acyclic chiral secondary amine

Victor Blanco  1 , David A Leigh, Vanesa Marcos, José A Morales-Serna, Alina L Nussbaumer
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A switchable [2]rotaxane asymmetric organocatalyst that utilizes an acyclic chiral secondary amine

Victor Blanco et al. J Am Chem Soc. .

Abstract

A rotaxane-based switchable asymmetric organocatalyst has been synthesized in which the change of the position of the macrocycle reveals or conceals an acyclic, yet still highly effective, chiral organocatalytic group. This allows control over both the rate and stereochemical outcome of a catalyzed asymmetric Michael addition.

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