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. 1988 Nov 15;256(1):147-52.
doi: 10.1042/bj2560147.

Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle

N D Carter  1 , P J Wistrand, H Isenberg, H Askmark, S Jeffery, D Hopkinson, Y Edwards
Affiliations

Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle

N D Carter et al. Biochem J. .

Abstract

Carbonic anhydrase III (CAIII) protein and mRNA amounts in fast- and slow-twitch rat muscles were examined after resection of the sciatic nerve. Striking changes occur in the fast-twitch anterior tibialis (AT) and extensor digitorum longus (EDL) muscles, where CAIII protein and mRNA are increased several-fold 16 days after denervation. The data suggest that these changes are regulated in part by changes in gene transcription and that they perhaps signal a fast-to-slow fibre type transition in these denervated muscles. AT and EDL show some differences in the effects of denervation, which are suggestive of variation in the timing of denervation-induced responses and/or the CAIII protein/mRNA turnover rates in the two muscles.

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