Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov 15;256(1):147-52.
doi: 10.1042/bj2560147.

Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle

N D Carter  1 , P J Wistrand, H Isenberg, H Askmark, S Jeffery, D Hopkinson, Y Edwards
Affiliations

Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle

N D Carter et al. Biochem J. .

Abstract

Carbonic anhydrase III (CAIII) protein and mRNA amounts in fast- and slow-twitch rat muscles were examined after resection of the sciatic nerve. Striking changes occur in the fast-twitch anterior tibialis (AT) and extensor digitorum longus (EDL) muscles, where CAIII protein and mRNA are increased several-fold 16 days after denervation. The data suggest that these changes are regulated in part by changes in gene transcription and that they perhaps signal a fast-to-slow fibre type transition in these denervated muscles. AT and EDL show some differences in the effects of denervation, which are suggestive of variation in the timing of denervation-induced responses and/or the CAIII protein/mRNA turnover rates in the two muscles.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Acta Soc Med Ups. 1960;65:249-57 - PubMed
    1. J Biol Chem. 1978 Jun 25;253(12):4143-52 - PubMed
    1. Dev Biol. 1979 Mar;69(1):15-30 - PubMed
    1. Exp Cell Res. 1980 May;127(1):75-87 - PubMed

Publication types