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. 1989 Jan 31;158(2):440-4.
doi: 10.1016/s0006-291x(89)80067-1.

Activation of platelet phospholipase C by fluoride is inhibited by elevation of cyclic AMP

E R Lazarowski  1 , E G Lapetina
Affiliations

Activation of platelet phospholipase C by fluoride is inhibited by elevation of cyclic AMP

E R Lazarowski et al. Biochem Biophys Res Commun. .

Abstract

Fluoride interacts with G proteins and, consequently, stimulates phospholipase C as measured by the formation of inositol phosphates and phosphatidic acid. In human platelets this paralleled platelet aggregation and the activation of phosphorylation of substrates of protein kinase C (47kDa protein) and myosin light chain kinase (20kDa protein). Phospholipase C activation by fluoride was inhibited by dibutyryl cyclic AMP and by agents that increase cyclic AMP levels such as iloprost and forskolin. This information suggest that cyclic AMP affects the G protein associated with the stimulation of phospholipase C.

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