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Multicenter Study
. 2014 Mar;7(3):244-54.
doi: 10.1016/j.jcin.2013.09.014.

Clinical impact of intravascular ultrasound guidance in drug-eluting stent implantation for unprotected left main coronary disease: pooled analysis at the patient-level of 4 registries

Jose M de la Torre Hernandez  1 , José A Baz Alonso  2 , Joan A Gómez Hospital  3 , Fernando Alfonso Manterola  4 , Tamara Garcia Camarero  5 , Federico Gimeno de Carlos  6 , Gerard Roura Ferrer  3 , Angel Sanchez Recalde  7 , Iñigo Lozano Martínez-Luengas  8 , Josep Gomez Lara  3 , Felipe Hernandez Hernandez  9 , María J Pérez-Vizcayno  4 , Angel Cequier Fillat  3 , Armando Perez de Prado  10 , Agustín Albarrán Gonzalez-Trevilla  9 , Manuel F Jimenez Navarro  11 , Josepa Mauri Ferre  12 , Jose A Fernandez Diaz  13 , Eduardo Pinar Bermudez  14 , Javier Zueco Gil  5 ; IVUS-TRONCO-ICP Spanish study
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Free article
Multicenter Study

Clinical impact of intravascular ultrasound guidance in drug-eluting stent implantation for unprotected left main coronary disease: pooled analysis at the patient-level of 4 registries

Jose M de la Torre Hernandez et al. JACC Cardiovasc Interv. 2014 Mar.
Free article

Abstract

Objectives: This study sought to investigate the clinical impact of the use of intravascular ultrasound (IVUS) during revascularization of patients with left main coronary artery (LM) disease with drug-eluting stents (DES).

Background: Whether the use of IVUS during the procedure adds a clinical benefit remains unclear. There is only 1 previous observational study, with relevant limitations, supporting the value of this strategy.

Methods: We performed a patient-level pooled analysis of 4 registries of patients with LM disease treated with DES in Spain. A propensity score-matching method was used to obtain matched pairs of patients with and without IVUS guidance.

Results: A total of 1,670 patients were included, and 505 patients (30.2%) underwent DES implantation under IVUS guidance (IVUS group). By means of the matching method, 505 patients without the use of IVUS during revascularization were selected (no-IVUS group). Survival free of cardiac death, myocardial infarction, and target lesion revascularization at 3 years was 88.7% in the IVUS group and 83.6% in the no-IVUS group (p = 0.04) for the overall population, and 90% and 80.7%, respectively (p = 0.03), for the subgroups with distal LM lesions. The incidence of definite and probable thrombosis was significantly lower in the IVUS group (0.6% vs. 2.2%; p = 0.04). Finally, IVUS-guided revascularization was identified as an independent predictor for major adverse events in the overall population (hazard ratio: 0.70, 95% confidence interval: 0.52 to 0.99; p = 0.04) and in the subgroup with distal lesions (hazard ratio: 0.54, 95% confidence interval: 0.34 to 0.90; p = 0.02).

Conclusions: The results of this pooled analysis show an association of IVUS guidance during percutaneous coronary intervention with better outcomes in patients with LM disease undergoing revascularization with DES.

Keywords: drug-eluting stent(s); intravascular ultrasound; left main coronary artery.

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