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Review
. 2014 Jun:26:22-6.
doi: 10.1016/j.conb.2013.11.003. Epub 2013 Nov 30.

Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

David A Lewis  1
Affiliations
Review

Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

David A Lewis. Curr Opin Neurobiol. 2014 Jun.

Abstract

Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein parvalbumin (PV). Recent studies have revealed new facets of the development of PV neurons in primate neocortex and of the nature of their molecular alterations in individuals with schizophrenia. Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development.

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Figures

Figure
Figure
Schematic drawing of pyramidal cell (P), parvalbumin basket call (PVBC) and PV chandelier cell (PVChC) circuitry in layer 3 of human DLPFC, illustrating the reported changes in schizophrenia. GAT1, GABA membrane transporter; PNNs, perineuronal nets.
See this image and copyright information in PMC

References

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