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Comment
. 2014 Mar 17;25(3):261-3.
doi: 10.1016/j.ccr.2014.03.001.

A jagged road to lymphoma aggressiveness

Vedran Radojcic  1 , Ivan Maillard  2
Affiliations
Comment

A jagged road to lymphoma aggressiveness

Vedran Radojcic et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Cao and colleagues identify an FGF4/Jagged1-driven crosstalk between tumor cells and their vascular niche that activates Notch signaling, sustaining the aggressiveness of certain mouse and human B cell lymphomas. These findings identify new therapeutic opportunities to target pathogenic angiocrine functions in cancer.

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Figures

Figure 1
Figure 1. Emerging roles of Notch in lymphoma pathogenesis
a. Structure of Notch1 and Notch2 receptors with sites of activating mutations previously reported in lymphoid malignancies. T-ALL - T cell acute lymphoblastic leukemia/lymphoma; CLL - chronic lymphocytic leukemia; MCL- mantle cell lymphoma; SMZL - splenic marginal zone lymphoma; ICN - intracellular Notch; HD - heterodimerization domain; TMD - transmembrane domain. b. Proposed model for crosstalk between lymphoma cells (LC) and endothelial cells (EC), with Jagged1/Notch2-driven effects on lymphoma aggressiveness(Cao et al., 2014). FGFR1 - fibroblast growth factor receptor 1; FGF4 - fibroblast growth factor 4; ICN - intracellular Notch.
See this image and copyright information in PMC

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References

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