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Comment
. 2014 Mar 17;25(3):265-7.
doi: 10.1016/j.ccr.2014.03.002.

The AML salad bowl

Jesús Duque-Afonso  1 , Michael L Cleary  2
Affiliations
Comment

The AML salad bowl

Jesús Duque-Afonso et al. Cancer Cell. .

Abstract

Tumors arise from single cells but become genetically heterogeneous through continuous acquisition of somatic mutations as they progress. In this issue of Cancer Cell, Klco and colleagues used whole genome sequence analysis to demonstrate the correlation of genetic clonal architecture with functional heterogeneity in acute myeloid leukemia.

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Figures

None
Functional and genetic heterogeneity of primary AML
A founding AML clone arises with accumulation of a set of acquired “signature” mutations. During tumor progression, the founding clone evolves into genetically distinct subclones through the acquisition of new mutations. The complete spectrum of mutations defines morphological and phenotypic properties of the subclones that correlate with distinct functional characteristics such as in vitro growth, engraftment in immune-deficient mice, or relapse in patients.
See this image and copyright information in PMC

Comment on

  • Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
    Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, Dipersio JF, Wilson RK, Ley TJ. Klco JM, et al. Cancer Cell. 2014 Mar 17;25(3):379-92. doi: 10.1016/j.ccr.2014.01.031. Epub 2014 Mar 6. Cancer Cell. 2014. PMID: 24613412 Free PMC article.

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