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Comment
. 2014 Mar 17;25(3):267-9.
doi: 10.1016/j.ccr.2014.03.003.

Therapeutic opportunities for medulloblastoma come of age

James M Olson  1
Affiliations
Comment

Therapeutic opportunities for medulloblastoma come of age

James M Olson. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Kool and colleagues reveal clear genetically defined subclasses of the sonic hedgehog (SHH) subclass of medulloblastoma. This molecular dissection of the SHH subclass is not simply a cutting-edge advance; the data have profound impact on clinical trial design and decision-making.

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Comment on

  • Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
    Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, Dipersio JF, Wilson RK, Ley TJ. Klco JM, et al. Cancer Cell. 2014 Mar 17;25(3):379-92. doi: 10.1016/j.ccr.2014.01.031. Epub 2014 Mar 6. Cancer Cell. 2014. PMID: 24613412 Free PMC article.

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