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Review
. 2014 Mar 20;10(3):e1003953.
doi: 10.1371/journal.ppat.1003953. eCollection 2014 Mar.

Mycobacteriophages: windows into tuberculosis

Graham F Hatfull  1
Affiliations
Review

Mycobacteriophages: windows into tuberculosis

Graham F Hatfull. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Diversity of mycobacteriophages.
Sequenced genomes for 471 mycobacteriophages were compared according to their shared gene contents, and the relationships are displayed using Splitstree . The genomes are clustered according to overall nucleotide sequence similarity, and the clusters (A, B, C…) correlate closely with their gene content. Colored circles encompass Clusters A–T as indicated, and grey circles represent singleton genomes that have no close relatives. Ten of the clusters are divided into subclusters (e.g., A1, A2, A3….) and are shown as circles within each cluster. Micrographs show the two morphotypes observed, typified by the myoviral Cluster C phages and the siphoviruses (all others) that primarily differ in tail length (scale bars, 100 nm). With the exception of one singleton (DS6A), all of the phages infect M. smegmatis mc2155. DS6A, the Cluster K phages and a subset of Cluster A phages also infect M. tuberculosis.
See this image and copyright information in PMC

References

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    1. Hatfull GF, Pedulla ML, Jacobs-Sera D, Cichon PM, Foley A, et al. (2006) Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform. PLOS Genet 2: e92 doi:10.1371/journal.pgen.0020092. - DOI - PMC - PubMed
    1. Hatfull GF (2012) Complete Genome Sequences of 138 Mycobacteriophages. J Virol 86: 2382–2384. - PMC - PubMed
    1. Hatfull GF (2013) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science [SEA-PHAGES] Program, KwaZulu-Natal Research Institute for Tuberculosis and HIV [K-RITH] Micobacterial Genomics Course, University of California—Los Angeles Research Immersion Laboratory in Virology, Phage Hunters Integrating Research and Education [PHIRE] Program (2013) Complete Genome Sequences of 63 Mycobacteriophages. Genome Announc 1: e00847–13. - PMC - PubMed

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