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. 2014 Feb;26(1):1-3.
doi: 10.3978/j.issn.1000-9604.2014.02.06.

Intraperitoneal chemotherapy and its evolving role in management of gastric cancer with peritoneal metastases

Emel Canbay  1 , Yutaka Yonemura  1 , Bjorn Brucher  1 , Seung Hyuk Baik  1 , Paul H Sugarbaker  1
Affiliations

Intraperitoneal chemotherapy and its evolving role in management of gastric cancer with peritoneal metastases

Emel Canbay et al. Chin J Cancer Res. 2014 Feb.

Abstract

Advanced gastric cancer (GC) has been recognized as lethal disease when peritoneal metastases (PM) occurred. There is no standard treatment for advanced GC with PM. Until 1980s, the therapeutic arena for these patients had remained stagnant, with no therapeutic approach having shown a survival gain in GC with PM. However, cytoreductive surgery (CRS) with peritonectomy procedures and intraperitoneal chemotherapy (IPC) promising new combined therapeutic approach to achieve disease control for GC with PM. The recent publications changed the GC with PM treatment landscape by providing an evidence that CRS and IPC led to prolongation in overall survival (OS). This review will provide an overview of the evolving role of CRS and IPC in the management of advanced GC with PM in the current era.

Keywords: Gastric cancer (GC); cytoreductive surgery (CRS); hyperthermic intraperitoneal chemotherapy (IPC); intraperitoneal and systemic induction chemotherapy; peritoneal carcinomatosis.

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