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Review
. 2014 Mar 15;7(1):37-41.
Epub 2014 Mar 25.

Osteoarthritis pathogenesis - a complex process that involves the entire joint

G S Man  1 , G Mologhianu  2
Affiliations
Review

Osteoarthritis pathogenesis - a complex process that involves the entire joint

G S Man et al. J Med Life. .

Abstract

Osteoarthritis is the most common joint disorder and a major cause of disability with a major socio-economic impact. In these circumstances is very important to understand its pathogenesis. Although previous research focused primarily on changes in the articular cartilage, more recent studies have highlighted the importance of the subchondral bone, synovium, menisci, ligaments, periarticular muscles and nerves. Now osteoarthritis is viewed as a multifactorial disease affecting the whole joint.

Keywords: cartilage; menisci; osteoarthritis; subchondral bone; synovium.

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References

    1. Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthtritis, Swiss Med Wkly. 2012;doi:10.4414/smw.2012.13583 - PubMed
    1. Solignac M. COART France 2003 report on new socioeconomic data on osteoarthritis in France. Presse Med. 2004;33:s4–s6. - PubMed
    1. Lawrence RC, Felson DT, Helmick CG. National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:26–35. - PMC - PubMed
    1. Kotlarz H, Gunnarsson CL, Fang H. Insurer and out-of-pocket costs of osteoarthritis in the U.S.: evidence from national survey data. Arthritis Rheum. 2009;60:3546–3553. - PubMed
    1. Dieppe P. Developments in osteoarthritis. Rheumatology. 2011;50:245–247. - PubMed

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