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Review
. 2013 Oct;8(4):351-8.

Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations

Nariman Nassiri  1 , Medi Eslani  2 , Nekoo Panahi  3 , Shiva Mehravaran  1 , Alireza Ziaei  4 , Ali R Djalilian  2
Affiliations
Review

Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations

Nariman Nassiri et al. J Ophthalmic Vis Res. 2013 Oct.

Abstract

Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided. The current review will focus on updated information regarding ocular GVHD.

Keywords: Allogeneic Stem Cell Transplantation; Bone Marrow Transplantation; Dry Eye; Keratoconjunctivitis Sicca; Ocular Graft Versus Host Disease.

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Figures

Figure 1
Figure 1
A Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) lens fitted over the eye of a patient with severe dry eye due to chronic graft versus host disease.
Figure 2
Figure 2
Severe corneal and conjunctival staining in a patient with chronic ocular graft versus host disease; this patient was started on autologous serum tears resulting in significant improvement of signs and symptoms.
See this image and copyright information in PMC

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