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. 2014 Mar 11:4:46.
doi: 10.3389/fonc.2014.00046. eCollection 2014.

Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in Cancer

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Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in Cancer

Sven Bilke et al. Front Oncol. .
No abstract available

Keywords: breast cancer; clonal evolution; copy number aberrations; epigenetics; mechanism.

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References

    1. Tang MH, Varadan V, Kamalakaran S, Zhang MQ, Dimitrova N, Hicks J. Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions. Front Oncol (2012) 2:197.10.3389/fonc.2012.00197 - DOI - PMC - PubMed
    1. Kamalakaran S, Kendall J, Zhao X, Tang C, Khan S, Ravi K, et al. Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation. Nucleic Acids Res (2009) 37(12):e89.10.1093/nar/gkp413 - DOI - PMC - PubMed
    1. Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Res (2003) 13(10):2291–30510.1101/gr.1349003 - DOI - PMC - PubMed
    1. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 3(6):415–2810.1038/nrg816 - DOI - PubMed
    1. De S, Michor F. DNA secondary structures and epigenetic determinants of cancer genome evolution. Nat Struct Mol Biol (2011) 18(8):950–510.1038/nsmb.2089 - DOI - PMC - PubMed

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