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. 2014 Apr;20(4):573-80.
doi: 10.3201/eid2004.131328.

Rotavirus surveillance in urban and rural areas of Niger, April 2010-March 2012

Anne-Laure Page, Viviane Jusot, Abdoul-Aziz Mamaty, Lagare Adamou, Jérôme Kaplon, Pierre Pothier, Ali Djibo, Mahamane L Manzo, Brahima Toure, Céline Langendorf, Jean-Marc Collard, Rebecca F Grais

Rotavirus surveillance in urban and rural areas of Niger, April 2010-March 2012

Anne-Laure Page et al. Emerg Infect Dis. 2014 Apr.

Abstract

Knowledge of rotavirus epidemiology is necessary to make informed decisions about vaccine introduction and to evaluate vaccine impact. During April 2010-March 2012, rotavirus surveillance was conducted among 9,745 children <5 years of age in 14 hospitals/health centers in Niger, where rotavirus vaccine has not been introduced. Study participants had acute watery diarrhea and moderate to severe dehydration, and 20% of the children were enrolled in a nutrition program. Of the 9,745 children, 30.6% were rotavirus positive. Genotyping of a subset of positive samples showed a variety of genotypes during the first year, although G2P[4] predominated. G12 genotypes, including G12P[8], which has emerged as a predominant strain in western Africa, represented >80% of isolates during the second year. Hospitalization and death rates and severe dehydration among rotavirus case-patients did not differ during the 2 years. The emergence of G12P[8] warrants close attention to the characteristics of associated epidemics and possible prevention measures.

Keywords: Africa; Niger; developing countries; diarrheal diseases; gastroenteritis; genotyping; malnutrition; rotavirus; rotavirus strain G12P[8]; surveillance; viruses.

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Figures

Figure
Figure
Number of rotavirus cases and extrapolated number of the 2 most frequent genotypes, G2P[4] and G12P[8], identified each month during a 2-year surveillance study in urban and rural areas of Niger, April 2010–March 2012. A) Cases in Niamey, the capital of Niger. B) Cases in Maradi region. Vertical bars indicate CIs.
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