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Comment
. 2014 Mar 18;106(6):1229-30.
doi: 10.1016/j.bpj.2014.02.003.

How does water pass through a sugar transporter?

Fangqiang Zhu  1
Affiliations
Comment

How does water pass through a sugar transporter?

Fangqiang Zhu. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Two proposed mechanisms for water transport in SGLT. For simplicity, only one solute is shown here, whereas in reality two types of solute (sugar and Na+) are involved. (A) A hypothetical molecular mechanism for the coupled transport (1). Each step in the transport cycle involves either a conformational transition (between the outward- and inward-facing states) or a collective binding / release of the solute and water molecules. A clockwise cycle in this diagram will result in a cotransport of solute and water into the cell. (B) The passive permeation mechanism (2), enabled by a water-conducting pore through the protein and driven by an osmotic gradient due to the directional transport of solute molecules.
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References

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