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Meta-Analysis
. 2014 Mar 21;9(3):e92773.
doi: 10.1371/journal.pone.0092773. eCollection 2014.

Recipient-related clinical risk factors for primary graft dysfunction after lung transplantation: a systematic review and meta-analysis

Yao Liu  1 , Yi Liu  1 , Lili Su  1 , Shu-juan Jiang  1
Affiliations
Meta-Analysis

Recipient-related clinical risk factors for primary graft dysfunction after lung transplantation: a systematic review and meta-analysis

Yao Liu et al. PLoS One. .

Abstract

Background: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Herein, we carried out a systematic review and meta-analysis of published literature to identify recipient-related clinical risk factors associated with PGD development.

Method: A systematic search of electronic databases (PubMed, Embase, Web of Science, Cochrane CENTRAL, and Scopus) for studies published from 1970 to 2013 was performed. Cohort, case-control, or cross-sectional studies that examined recipient-related risk factors of PGD were included. The odds ratios (ORs) or mean differences (MDs) were calculated using random-effects models.

Result: Thirteen studies involving 10042 recipients met final inclusion criteria. From the pooled analyses, female gender (OR 1.38, 95% CI 1.09 to 1.75), African American (OR 1.82, 95%CI 1.36 to 2.45), idiopathic pulmonary fibrosis (IPF) (OR 1.78, 95% CI 1.49 to 2.13), sarcoidosis (OR 4.25, 95% CI 1.09 to 16.52), primary pulmonary hypertension (PPH) (OR 3.73, 95%CI 2.16 to 6.46), elevated BMI (BMI≥25 kg/m2) (OR 1.83, 95% CI 1.26 to 2.64), and use of cardiopulmonary bypass (CPB) (OR 2.29, 95%CI 1.43 to 3.65) were significantly associated with increased risk of PGD. Age, cystic fibrosis, secondary pulmonary hypertension (SPH), intra-operative inhaled nitric oxide (NO), or lung transplant type (single or bilateral) were not significantly associated with PGD development (all P>0.05). Moreover, a nearly 4 fold increased risk of short-term mortality was observed in patients with PGD (OR 3.95, 95% CI 2.80 to 5.57).

Conclusions: Our analysis identified several recipient related risk factors for development of PGD. The identification of higher-risk recipients and further research into the underlying mechanisms may lead to selective therapies aimed at reducing this reperfusion injury.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow of study identification, inclusion, and exclusion.
Figure 2
Figure 2. The influence of recipient gender on PGD.
Figure 3
Figure 3. The influence of African American and Hispanic race on PGD compared with white race.
Figure 4
Figure 4. The influence of recipient pulmonary diagnosis on PGD.
COPD was used as the reference group.
Figure 5
Figure 5. The influence of recipient pulmonary hypertension on PGD.
COPD was used as the reference group.
Figure 6
Figure 6. The influence of mean pulmonary artery pressures (PAP) on PGD.
Figure 7
Figure 7. The influence of PGD on short-term mortality (mortality within 90 days).
Figure 8
Figure 8. Funnel plot of the 12 studies evaluated the effect of the recipient gender on PGD.
See this image and copyright information in PMC

References

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