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Meta-Analysis
. 2014 Mar 21;9(3):e92485.
doi: 10.1371/journal.pone.0092485. eCollection 2014.

Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis

Nalinee Poolsup  1 , Naeti Suksomboon  2 , Muhammad Amin  2
Affiliations
Meta-Analysis

Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis

Nalinee Poolsup et al. PLoS One. .

Abstract

Objective: To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care.

Methods: A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any form of therapeutic intervention in comparison to usual antenatal care. A literature search was conducted using electronic databases together with a hand search of relevant journals and conference proceedings.

Results: Ten studies involving 3,881 patients contributed to meta-analysis. Our results indicated that gestational diabetes mellitus treatment significantly reduced the risk for macrosomia (RR, 0.47; 95% CI, 0.38-0.57), large for gestational age births (RR, 0.55; 95% CI, 0.45-0.67), shoulder dystocia (RR, 0.42; 95% CI, 0.23-0.77) and gestational hypertension (RR, 0.68; 95% CI, 0.53-0.87) without causing any significant increase in the risk for small for gestational age babies. However, no significant difference was observed between the two groups regarding perinatal/neonatal mortality, neonatal hypoglycemia, birth trauma, preterm births, pre-eclampsia, caesarean section and labor induction.

Conclusion: Treating GDM reduces risk for many important adverse pregnancy outcomes and its association with any harm seems unlikely.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart of article selection
Figure 2
Figure 2. Risk of bias graph
Figure 3
Figure 3. Risk of bias summary
Figure 4
Figure 4. Effects of treatment on perinatal / neonatal outcomes
Figure 5
Figure 5. Effects of treatment on maternal outcomes
See this image and copyright information in PMC

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