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Comment
. 2014 May 15;20(10):2505-7.
doi: 10.1158/1078-0432.CCR-14-0370. Epub 2014 Mar 21.

Minimal residual disease in breast cancer: in blood veritas

Giulia Siravegna  1 , Alberto Bardelli  2
Affiliations
Free article
Comment

Minimal residual disease in breast cancer: in blood veritas

Giulia Siravegna et al. Clin Cancer Res. .
Free article

Abstract

A blood-based molecular test might direct recommendations for systemic therapies in patients with early-stage breast cancer undergoing surgery with curative intent. A new study suggests that droplet digital PCR (ddPCR) can be used to detect cancer-specific DNA alterations in plasma with sensitivity suitable for monitoring minimal residual disease.

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  • Detection of cancer DNA in plasma of patients with early-stage breast cancer.
    Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky DJ, Wong HY, Toro PV, Cidado J, Blair BG, Chu D, Burns T, Higgins MJ, Stearns V, Jacobs L, Habibi M, Lange J, Hurley PJ, Lauring J, VanDenBerg D, Kessler J, Jeter S, Samuels ML, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC, Park BH. Beaver JA, et al. Clin Cancer Res. 2014 May 15;20(10):2643-2650. doi: 10.1158/1078-0432.CCR-13-2933. Epub 2014 Feb 6. Clin Cancer Res. 2014. PMID: 24504125 Free PMC article.

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