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Meta-Analysis
. 2014 Jan-Feb;34(1):12-7.
doi: 10.5144/0256-4947.2014.12.

The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis

Ying Liu, Zhiyun Wang, Benshu Zhang  1
Affiliations
Meta-Analysis

The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis

Ying Liu et al. Ann Saudi Med. 2014 Jan-Feb.

Abstract

Background and objectives: Many studies were conducted to assess the relationship between Monoamine oxidase B (MAOB) A644G polymorphism and susceptibility to Parkinson disease (PD). However, the results were inconsistent and inconclusive.

Design and settings: A meta-analysis was conducted from all published studies on the associations between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease.

Methods: In this present study, the possible relationship between MAOB A644G polymorphism and PD risk was assessed by a meta-analysis. Eligible articles were identified for the period up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed-effects models.

Results: Twenty case-control studies with a total of 2846 cases and 3508 controls were eligible. In a recessive model, MAOB A644G polymorphism was associated with PD risk (OR=1.32, 95% CI 1.18-1.47, P < .001). Subgroup analyses by ethnicity and gender also found significant relationships between this polymorphism and PD risk.

Conclusion: This meta-analysis suggested that MAOB A644G polymorphism may be associated with PD development.

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Figures

Figure 1
Figure 1
Flow of study identification, inclusion, and exclusion.
Figure 2
Figure 2
Meta-analysis for the relationship between the MAOB A644G polymorphism and PD risk.
Figure 3
Figure 3
Cumulative meta-analysis of relationship between the MAOB A644G polymorphism and PD risk.
Figure 4
Figure 4
Sensitivity analysis for the MAOB A644G polymorphism and PD risk.
Figure 5
Figure 5
Funnel plot for publication bias test in the meta-analysis investigating the relationship between the MAOB A644G polymorphism and PD risk.
See this image and copyright information in PMC

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References

    1. Fritsch T, Smyth KA, Wallendal MS, Hyde T, Leo G, Geldmacher DS. Parkinson Disease: Research Update and Clinical Management. South Med J. 2012;105:650–6. - PubMed
    1. Zimprich A. Genetics of Parkinson’s disease and essential tremor. Curr Opin Neurol. 2011;24:318–23. - PubMed
    1. Langston JW. Epidemiology versus genetics in Parkinson’s disease: progress in resolving an age-old debate. Ann Neurol. 1998;44:S45–S52. - PubMed
    1. Steventon G, Sturman S, Heafield M, Waring R, Napier J, Williams A. Platelet monoamine oxidase-B activity in Parkinson’s disease. J Neural Transm Park Dis Dement Sect. 1989;1:255–61. - PubMed
    1. Kumar MJ, Andersen JK. Perspectives on MAO-B in aging and neurological disease: Where do we go from here? Mol Neurobiol. 2004;30:77–89. - PubMed

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