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. 2014 Nov;28(6):461-4.
doi: 10.1002/jcla.21710. Epub 2014 Mar 22.

Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms

Ying-Ju Lin  1 , Yu-Ching Lan, Chih-Ho Lai, Ting-Hsu Lin, Shao-Mei Huang, Chiu-Chu Liao, Cheng-Wen Lin, Chien-Hui Hung, Ni Tien, Xiang Liu, Wen-Kuei Chien, Jin-Hua Chen, Fuu-Jen Tsai
Affiliations

Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms

Ying-Ju Lin et al. J Clin Lab Anal. 2014 Nov.

Abstract

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients.

Methods: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study.

Results: Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98).

Conclusion: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

Keywords: Kawasaki disease; coronary artery aneurysms; genetic polymorphism; interleukin-10.

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