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Editorial
. 2014 Mar;100(3):127-33.
doi: 10.1002/bdra.23242.

Developmental determinants and changing patterns of respiratory outcomes after preterm birth

Steven H Abman  1 , Simon J Conway
Affiliations
Editorial

Developmental determinants and changing patterns of respiratory outcomes after preterm birth

Steven H Abman et al. Birth Defects Res A Clin Mol Teratol. 2014 Mar.

Erratum in

  • Birth Defects Res A Clin Mol Teratol. 2014 Oct;100(10):811
No abstract available

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Figures

Figure 1
Figure 1. Histological presentation of new BPD
(A,B) Histology of a patient with fatal new BPD, demonstrating increased distal airspaces with decreased sepatation and reduced alveolarization (A); as well as pulmonary vascular wall thickness is present in small arteries (arrow in B), suggestive of pulmonary hypertension. (C,D) Confocal images of postnatal day 7 mouse lungs exposed to either room air (C) or 85% O2 hyperoxia (D) from birth onwards. Note that the hyperoxic lung exhibits reduced alveolarization, exemplifying the alterations in distal airspace that mimics new BPD, a chronic lung disease characterized by impaired gas exchange commonly found in extremely premature infants exposed to mechanical ventilation and oxygen supplementation. Nuclei are stained with DAPI (blue) and green signal is extracellular matrix autofluorescence.
See this image and copyright information in PMC

References

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    1. Alvira C. Nuclear factor kappa B signaling in lung development and disease: one pathway, numerous functions. Birth Defects Research Part A: Clinical and Molecular Teratology. 2014 in press. - PMC - PubMed
    1. Ambalavanan N, Mourani P. Pulmonary hypertension in BPD. Birth Defects Research Part A: Clinical and Molecular Teratology. 2014 in press. - PubMed

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