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. 2015 Jan;29(1):5-9.
doi: 10.1002/jcla.21718. Epub 2014 Mar 22.

Serum leptin is associated with metabolic syndrome in obese Mexican subjects

Sara García-Jiménez  1 , German Bernal Fernández, Maria Fernanda Martínez Salazar, Antonio Monroy Noyola, Cairo Toledano Jaimes, Angelica Meneses Acosta, Leticia Gonzalez Maya, Elizabeth Aveleyra Ojeda, Maria A Terrazas Meraz, Marie-Catherine Boll, Miguel A Sánchez-Alemán
Affiliations

Serum leptin is associated with metabolic syndrome in obese Mexican subjects

Sara García-Jiménez et al. J Clin Lab Anal. 2015 Jan.

Abstract

Background: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities including insulin resistance, dyslipidemia, high blood pressure, and abdominal adiposity. Obese patients develop leptin resistance, and an increased waist circumference (WC) due to deposition of abdominal fat. The aim of this study was to evaluate the association between circulating leptin levels and MetS among sample adult Mexican workers.

Method: A total of 204 workers aged 20-56 were evaluated. Anthropometric index, blood pressure, fasting plasma glucose, and lipid profile were measured by spectrophotometric methods. Fasting insulin and leptin were measured by inmunoenzimatic methods. Furthermore, homeostasis model assessment for insulin resistance (HOMA-IR) was calculated.

Results: The prevalence of MetS according to the ATP-III criteria was 33.8% and leptin concentrations were 2.5 times higher in women than men. Subjects with MetS had higher levels of leptin (26.7 ± 13.7) compared with those without MetS (20.1 ± 13.9; P <0.001). Leptin increased significantly while BMI increased as well (normal 14.0 ± 8.9, overweight 22.7 ± 11.7 and obese 31.4 ± 14.6) in addition to other variables such as WC, HDL-C, insulin levels, and HOMA index. Each component of MetS was stratified by sex and submitted by linear regression with a 95% of accuracy. The 50% and 53% of the BMI is explained by the concentration of leptin in men and women, respectively (P < 0.001).

Conclusion: This study found that leptin was associated with the MetS, especially in obesity and insulin resistance, indicating a high risk for university workers to develop hypertension, DM2, and cardiovascular disease.

Keywords: leptin; metabolic syndrome; obesity.

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Figures

Figure 1
Figure 1
The 50% and 53% of the body mass index (BMI) is explained by the concentration of leptin in men and women, respectively. For each nanogram per milliliters of leptin increased, the BMI is increased by 0.45 for men and 0.28 for women.
See this image and copyright information in PMC

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