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. 2014 Jan-Mar;19(1):130-6.

The effect of nitidine chloride on the proliferation and apoptosis of nasopharyngeal carcinoma cells

Min Kang  1 , Hesheng Ou, Rensheng Wang, Wenqi Liu, Anzhou Tang
Affiliations
  • PMID: 24659654
Free article

The effect of nitidine chloride on the proliferation and apoptosis of nasopharyngeal carcinoma cells

Min Kang et al. J BUON. 2014 Jan-Mar.
Free article

Abstract

Purpose: This study was conducted to investigate the effect of nitidine chloride (NC) on the proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE1, CNE2, TWO3, and C666-1, and to explore its antitumor mechanism.

Methods: NC was dissolved in IMDM medium and cultured with nasopharyngeal carcinoma cell line CNE1, CNE2, TWO3 and C666-1. Cell morphology, cell proliferation, cell apoptosis, p53 mRNA and p53 protein levels were assessed.

Results: After incubation with NC for 24 h, typical apoptotic morphology was observed. NC inhibited the proliferation and induced apoptosis of all 4 cell lines in a time-dose dependent manner. p53 mRNA and p53 protein levels were significantly increased.

Conclusions: NC inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cells with upregulation of p53 gene.

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