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Review
. 2014 Mar 21;20(11):2751-9.
doi: 10.3748/wjg.v20.i11.2751.

Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

Jeong Bae Park  1 , Ja Seol Koo  1
Affiliations
Review

Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

Jeong Bae Park et al. World J Gastroenterol. .

Abstract

Gastrointestinal lymphoma is the most common type of extranodal lymphoma, and most commonly affects the stomach. Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and diffuse large B-cell lymphoma are the most common histologic types of gastric lymphoma. Despite its increasing incidence, diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings, and, thus, a high index of suspicion, and multiple, deep, repeated biopsies at abnormally and normally appearing sites in the stomach are needed. In addition, testing for Helicobacter pylori (H. pylori) infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to H. pylori eradication and for assessment of disease progression. In addition, H. pylori infection and MALT lymphoma development are associated, and complete regression of low-grade MALT lymphomas after H. pylori eradication has been demonstrated. Radiotherapy and/or chemotherapy can be used in cases that show poor response to H. pylori eradication, negativity for H. pylori infection, or high-grade lymphoma.

Keywords: Eradication; Helicobacter pylori; Lymphoma; Mucosa-associated lymphoid tissue; Remission.

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Figures

Figure 1
Figure 1
Variable endoscopic findings of gastric mucosa-associated lymphoid tissue lymphoma. A: Single erosive type; B: Ulcerative type; C: Atrophic type; D: Cobblestone-mucosa type; E: Nodular type; F: IIc-like type.
Figure 2
Figure 2
Histopathological and immunohistochemical features of gastric mucosa-associated lymphoid tissue lymphoma. A: Histopathological finding. Gastric MALT lymphoma shows many lymphoepithelial lesions formed by the invasion of glands by centrocyte-like cells [hematoxylin and eosin (HE) stain, × 400]; B: Immunohistochemical finding. Centrocyte-like cells show strong positive signals for CD20 (× 400).
Figure 3
Figure 3
Ann Arbor staging system modified by Musshoff and suggested therapeutic algorithm for gastric mucosa-associated lymphoid tissue lymphoma. H.pylori: Helicobacter pylori.
See this image and copyright information in PMC

References

    1. Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, et al. Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut. 2012;61:646–664. - PubMed
    1. Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102:1808–1825. - PubMed
    1. Fujioka T, Yoshiiwa A, Okimoto T, Kodama M, Murakami K. Guidelines for the management of Helicobacter pylori infection in Japan: current status and future prospects. J Gastroenterol. 2007;42 Suppl 17:3–6. - PubMed
    1. Caselli M, Zullo A, Maconi G, Parente F, Alvisi V, Casetti T, Sorrentino D, Gasbarrini G. “Cervia II Working Group Report 2006”: guidelines on diagnosis and treatment of Helicobacter pylori infection in Italy. Dig Liver Dis. 2007;39:782–789. - PubMed
    1. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–577. - PubMed

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