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. 2014 May;35(5):303-4.
doi: 10.1016/j.placenta.2014.02.012. Epub 2014 Mar 6.

The Human Placenta Project: placental structure, development, and function in real time

A E Guttmacher  1 , Y T Maddox  1 , C Y Spong  2
Affiliations

The Human Placenta Project: placental structure, development, and function in real time

A E Guttmacher et al. Placenta. 2014 May.

Abstract

Despite its crucial role in the health of both the fetus and the pregnant woman, the placenta is the least understood human organ. Since a growing body of evidence also underscores the importance of placental development in the lifelong health of both mother and offspring, this lack of knowledge about placental structure and function is particularly concerning. Given modern approaches and technologies and the ability to develop new methods, we propose a coordinated "Human Placenta Project", with the ultimate goal of understanding human placental structure, development, and function in real time.

Keywords: Human placenta; Research.

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References

    1. Lacroix M, Kina E, Hivert MF. Maternal/fetal determinants of insulin resistance in women during pregnancy and in offspring over life. Curr Diab Rep. 2013;13(2):238–44. - PubMed
    1. McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol. 2004;24(6):540–7. - PubMed
    1. Fisher SJ. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2:53. - PMC - PubMed
    1. Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ. Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest. 2013;123(7):2862–72. - PMC - PubMed
    1. Silasi M, Cohen B, Karumanchi SA, Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010;37(2):239–53. - PubMed